Guillermo A. Herrera, MD

I graduated from the University of Puerto Rico, School of Medicine. I trained at Fort Sam Houston, Texas in Anatomic and Clinical Pathology and remained in the US Army serving at Walter Reed and William Beaumont Army Medical Centers. I retired from the Army as colonel.

My main interest include understanding of pathogenesis of renal disorders occurring in patients with plasma cell dyscrasias. Translational studies during my career have provided an understanding of how the kidneys are affected in myeloma. Bone research conducted in my laboratory has provided unique insight into diseases such as AL-amyloidosis and light/heavy chain deposition disorders. Key steps in the pathogenesis of these diseases have been uncovered paving the way to develop innovative therapeutic approaches.

I am a member of several editorial boards of prestigious journals and have participated in a number of NIH study sections. Most recently I was named a member of an NIH panel composed of well recognized scientists working in amyloid pathogenesis and mechanisms of cellular damage.

I am currently the President of the Renal Pathology Society, a society composed of about 400 international and national members.

Previous positions within medical schools include:

1991 - 1995
University of Alabama at Birmingham (Director of Surgical Pathology)
1989 - 1991
University of Mississippi (Director of Surgical Pathology)
1996 - 2006
Louisiana State University Health Shreveport (Chairman)
2006 - 2008
St. Louis University (Chairman)
2008 - 2012
Bostwick Laboratories (Developing 4th largest nephropathology service in the world)
2012 - present
Louisiana State University Health Shreveport (Chairman))

Board Certifications

1979 -
Anatomic and Clinical Pathology
1991 -
2004 -
Anatomic and Clinical Pathology Recertification

Awards and National Recognition

2007 -
Distinguished Scientist Award for Contributions to Science, University of South Alabama Health Sciences Center
2006 -
Tatiana T. Antanovych, M.D. Award, Armed Forces Institute of Pathology
1994 - 1995
Leonard H Robinson Award for Excellence in Resident Education in Anatomic Pathology, University of Alabama, Birmingham
1992 - 1993
Resident Teacher Award in Recognition of Commitment to and Excellence in Resident Education in Anatomic Pathology, University of Alabama at Birmingham
1991 -
National Defense Medal

Research Interest

Renal Pathology in Plasma Cell Dyscrasias
Diagnosis and Pathogenesis of Amylosidosis

Selected Publications

Book Chapters

Herrera GA, Lott RL: Colloidal gold labeling for diagnostic pathology. In Colloidal Gold: Principles, Methods, and Applications (M.A. Hayat, Ed.) Vol. 3. Academic Press, San
Diego and London, 1990, Chapter 16, pp. 321-345.

Herrera GA, Turbat-Herrera EA, Bradley D: Current practices in the immunomorphologic evaluation of tumors in surgical pathology. A comprehensive approach with emphasis on
immunolabeling at the light and ultrastructural level. In Electron Microscopic Cytochemistry and Immunocytochemistry in Biomedicine. (T. Barka and K. Ogawa, Eds.). CRC Press
Inc., Boca Raton, Florida, 1993, Chapter 19, pp. 739-780.

Turbat-Herrera EA, Harkins L, Herrera GA: Immunoelectron microscopy in diagnostic pathology. In Immunohistochemistry and Immunopathology. Section H, Chapter 50. Manual of Clinical Laboratory Immunology. 5th Ed. (CR Taylor, Ed.) American Society of Microbiology Press, Washington, D.C., 1997, pp. 431-443.

Herrera GA, Turbat-Herrera EA: The state of the art in the diagnosis of mesothelioma. In Sourcebook on Asbestos Diseases, Volume 18. Chapter 10. (G.A. Peters & B. J. Peters, Eds.). Lexis Law Publishing/Reed Elsevier Inc., Charlottesville, VA, 1998, pp. 219-267.

Solomon A, Weiss DT, Herrera GA: Light chain deposition disease: clinicopathologic and biologic features. In Myeloma (J. Mehta and S. Singhal, Eds.) Chapter 29. Martin Dunitz Ltd. Pub, Oxford, England, 2002, pp. 507-518.

Solomon A, Weiss, DT, Herrera GA: Renal diseases associated with multiple myeloma and related plasma cell dyscrasias. In Biology and Management of Multiple Myeloma (J. Berenson, Ed.) Chapter 14, Humana Press, Totowa, NJ, 2004, pp. 281-302.

Herrera GA, Picken MM: Renal diseases associated with plasma cell dyscrasias, amyloidoses, Waldenström macroglobulinemia and cryoglobulinemic nephropathies. In Heptinstall’s Pathology of the Kidney. 6th Ed. Chapter 19 (JC Jennette, JL Olson, MM Schwartz and FG Silva, Eds.) Lippincott-Raven, Pub., Philadelphia, New York, 2006 pp. 853-910.

Publications / Presentations / Abstracts / Posters:

Hutchinson, CA, Batuman, V, Behrens, J, Bridoux, F, Sirac, C, Dispenzieri, A, Herrera, GA, Lachmann, H, Sanders, PW: The pathogenesis and diagnosis of acute kidney injury in multiple myeloma. Nat Rev Nephrol 8: 43-51, 2011.

Herrera GA: Renal lesions associated with plasma cell dyscrasias: Practical approach to diagnosis, new concepts, and challenges. Arch Pathol Lab Med 133: 249-267, 2009.

Herrera, GA, Turbat-Herrera, EA: Renal diseases with organized deposits: An algorithmic approach to classification and diagnosis. Arch Pathol Lab Med 134: 512-531, 2010.

Herrera, GA, Turbat-Herrera: Ultrastructural immunolabeling in the diagnosis of monoclonal light and heavy chain-related renal diseases. Ultrastruct Pathol 34: 161-173, 2010.

Keeling J, Herrera GA: An in-vitro model of light chain deposition disease. Kidney Int 75: 634-645, 2009.

Keeling J, Herrera GA: Matrix metalloproteinases and mesangial remodeling in light chain-related glomerular damage. Kidney Int 68:1590-1603, 2005.

Keeling J, Teng J, Herrera GA: AL-amyloidosis and light chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. Lab Invest 84:1322-1338, 2004.